理肠饮对腹泻型肠易激综合征内脏高敏性干预临床及实验的研究.pdfVIP

Clinical and Experimental Study on Li Chang-yin in Treating visceral hypersensitivity of Diarrhea-Irritable Bowel Syndrome Speciality:Integrative Medicine Auther:Xu Hai-xiao Tutor:Chi Li-li Abstract Objective:In this paper, based on previous studies, both from clinical and animal experiments to further evaluate the efficacy of Li Chang-yin in Treating diarrhea-irritable bowel syndrome (D-IBS), and Observe the intervention on visceral hypersensitivity, and the science of theoretical and experimental basis for Chinese medicine treatment of the disease. Methods:(一)Clinical research:160 patients met the inclusion criteria were randomly divided into experimental group (80 cases) and control group (80 cases), respectively, give Li Chang-yin and Dicetel(Pinaverium bromide) oral treatment lasted four weeks.Observed after treatment there are always efficiency and efficacy of TCM symptoms, adverse reactions and the relapse rate. (二)Experimental study:120 rats were randomly divided into blank control group (group A, 20); model control group (group B, 20);Li Chang-yin, in the Low, medium and high dose group (C and D and Group E, 20); western medicine the Dicetel group (group F, 20).Using colon chronic stimulation modeling,after modeling success each group to its corresponding drug orally,after 2 weeks observed the changes in the serum, colon tissue 5-HT, SP levels. (三)Resuit:(一)Results of clinical studies show:1.After treatment, the total efficiency compared: the experimental group was 91.25% and 71.25% in the control group, the experimental group than the control group, the difference was statistically significant (P 0.01).2.The two groups in the TCM Syndrome, total symptom score were improved after treatment than