34株慢速生长非结核分枝杆菌针对一线和二线抗结核药物的敏感性试验研究.pdfVIP

Chinese Journal of Zoonoses DOI 10 3969 issn 1002 2694 2015 10 004 j Drug sensitivity of thirty four reference slowly growing mycobacteria to first and second line antituberculous agents PANG Hui LI Guilian WAN Kanglin YU Ping Dep artment of Immunology X iangy a School of Medicine Central South University Changsha China Dep artment of Immunology Changz hi Medical Colle ge Changz hi China State Key L aboratory f or Inf ectious Disease Prevention and Control N ational Institute f or Communicable Disease Control and Prevention Chinese Center f or Disease Control and Prevention Beij ing China Collaborative Innov ation Center f or Diag nosis and T reatment of Inf ectious Diseases H angz hou China Abstract Slowly growing mycobacteria SGM are distributed in the environment for example in soil and dirty water SGM can cause human infections especially lung diseases In this article first and second line antituberculous agents were ex amined in order to identify the optimum drugs for the treatment of SGM disorders The fewest SGM in our study were susceptible to isoniazid Rifampicin and ethambutol were effective against similar numbers of strains Ofloxa cin kanamycin tobramycin and streptomycin were active against most of the tested strains Ciprofloxacin levofloxacin amikacin and capreomycin showed an excellent range of activity Moxifloxacin showed the widest range of activity against the SGM species Among the tested SGM spe cies M simiae and M af ricanu