《Optimal control analysis of hepatitis C virus with acute and chronic stages in the presence of treatment and infected immigrants.》.pdf

下载文档 降价啦

9
0
约4.77万字
约 23页
2015-12-02 发布于河南
举报
版权申诉
保障服务

《Optimal control analysis of hepatitis C virus with acute and chronic stages in the presence of treatment and infected immigrants.》.pdf

1、本文档共23页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。

InternationalJournalofBiomathematics !墨璺皇!fj壁 Vo1．7，No．2(2014)1450019(23pages) WWW W0rlclscientlficCOm ⑥ WorldScientificPublishingCompany DOh iO．1142／4500193 Optim alcontrolanalysisofhepatitisC viruswith acute and chronic stagesin thepresenceoftreatmentand infected imm igrants Kazeem 0areOkosun DepartmentofMathematics UniversityofTechnology PrivateBagX021，Vanderbijlpark1900 SouthAfrica kazeemoare~gm ail．corn 0luwoleDanielMakinde FacultyofMilitaryScience SteUenbosch University，PrivateBagX2 Saldanha7395，SouthAfrica makinded~gm ail．CO?n Received 12M arch 2O13 Accepted 25February2014 Published 24M arch 2014 Inthispaper，weconsideradeterministichepatitisCvirus(HCV)modelandstudythe impactofoptim a1controlonthescreeningofimm igrantsand treatmentofHCV onthe transm issiondynam icsofthediseaseinahomogeneouspopulationw ithconstantimnii— grationofsusceptibles．First，wederivedthecondition inwhichdisease-freeequilibrium iSlocally asymptotically stable and established thata stabledisease-free equilibrium canonlybeachieved in theabsenceofinfectiveimmigrants．Second．weinvestigatedthe impactofeachcontrolmechanism individuallyandthecombinationsofthesestrategies inthecontrolofHCV．Thecostsassociatedwitheachofthesestrategiesarealsoinves— tigated by fi,rmulatingthecostsfunction problem asanoptimalcontrolp