《介孔羟基磷灰石纳米粒子的制备及作为蛋白类缓释药物载体的应用》.pdfVIP

２０１５ ３ （） March ２０１５ ３９ ２ Journalof Anhui University （Natural Science Edition） Vol．３９ No．２ doi ：１０ ．３９６９／ ．issn．１０００‐２１６２ ．２０１５ ．０２ ．０１５ j ，* （， ２３０６０１） ：（HA），X（XRD）、 （TEM）、（BET）、（BJH）、（FT‐IR） ． ，， Langmuir． ‐ H， H p p ， Korsmeyer‐Peppas ， Fickian． ：；；； ：O６４７•３１ ：A ：１０００‐２１６２（２０１５）０２‐００８９‐０８ Preparation of mesoporous hydroxyapatite nanoparticles and application as a controllable release carrier of protein * HE Xiao‐mei，GU Li‐na （Collegeof Chemistry andChemical Engineering ，Anhui University ，Hefei２３０６０１ ，China） Abstract ：Mesoporous hydroxyapatite （HA） nanoparticles were synthesized via gas‐liquid chemicalprecipitationcombining withhydrothermalmethod ．Andthestructure，morphology and pore size distribution of HA were observed and measured using the X‐ray powder diffraction （XRD）， transmission electron microscopy （TEM ）， Brunauer‐Emmett‐Teller （BET ）， Barret‐Joyner‐Halenda scheme （ BJH ） and Fourier transform infrared spectrophotometer （FT‐IR）．The adsorption isotherms of bovine serum albumin （BSA） on as‐ repared HA at various temperatures were obtained and the corresponding equilibriump datafittedbetter theLangmuir modelbetter ．Meanwhile，theBSA cumulativereleaserateof the BSA‐loaded HA was investigated．The release rate was different at different pH values due to the effect of charge repulsion．Furthermore，thevitro releasewasin accordance with the Korsmeyer‐Peppasequation and the release mechanism fitted the non‐Fickian diffusion． Key words ：nanoparticles；hydroxyapati