《Effects of simvastatin on cigarette smoke extract induced tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in human umbilical vein endothelial cells》.pdfVIP
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《Effects of simvastatin on cigarette smoke extract induced tissue-type plasminogen activator and plasminogen activator inhibitor-1 expression in human umbilical vein endothelial cells》.pdf
2380 ChinMedJ 9J:2380—2385
2009;122(1
article
Original
Effectsofsimvastatinon smokeextractinduced
cigarette
activatorand activator
tissue--typeplasminogen plasminogen
;in;ndothelial0Ulellalcells
inhibitor-1ito ex SSlOninhumanumanam|Ileallmbilicalvelnell
pre5
HU ChenandYANGYuan-hua
Xiao—yun,MAYu—hui,WANG
smoke activatorinhibitor-l;
Keywords:cigaretteextract;simvastatin;tissue—typeactivator;plasminogen
plasminogen
humanumbilicalvascularendotheliaZcells
hasanjnfluenceonboth and is
BackgroundCigarettesmoking arterial-typevenous.type
known the umbilicaIveinendotheliaI
aboutdirecteffectof smoke ofhuman
cigaretteextract(CSE)onfibrinolyticactivity
cells and
hasbeenmarkedinitseffectonendotheliaI
cells(HUVECs).Mostrecently,simvastatin protection
this effectofCSEonthe of
anticoagulation.Instudy,the expressiontissue·typeplasminogen
activator roleofsimvastatininCSE-induced
inhibitor·1(PAl一1)inHUVECswasaddressed.The fibrinolytic
plasminogen
was aswell.
activitychanges
investigated
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