初诊2型糖尿病胰岛素强化治疗120例临床分析.docVIP

初诊2型糖尿病胰岛素强化治疗120例临床分析 吴丽雅，张维新 （重庆市渝北区人民医院? 401120） 摘? 要：目的? 探讨早期胰岛素强化治疗对初诊2型糖尿病（T2DM）患者血糖控制达标的疗效。方法? 将我院120例初诊T2DM患者予胰岛素强化治疗，作为治疗组；另选取120例初诊T2DM患者予口服药物治疗，作为对照组。分别观察2个月后各组空腹血糖（FBG）、餐后2h血糖（PBG）,糖化血红蛋白（HbAlc）、胰岛素水平、C肽水平变化情况。强化治疗后随访1年，观察疗效。结果? 经胰岛素强化治疗后FBG、PBG、HbAlc等显著下降，空腹及餐后2h胰岛素水平、C肽水平，比对照组明显增高，差别有统计学意义（P＜0.01）。结论? 胰岛素强化治疗组疗效明显优于对照组，能更有效地控制血糖水平，降低高糖毒性，减轻胰岛素抵抗，使胰岛细胞功能恢复。 关键词：2型糖尿病；胰岛素；强化冶疗 中图分类号：R587.2 ???????????文献标识码：A?????????? 文章编号： Clinic Analysis of Intensive Insulin Therapy in 120 Newly Diagnosed Type 2 Diabetic Patients Wu liya, Zhang weixin???? CHONGKING YUBEI People’s Hospital, 401120 [Abstract] Objective ?To study the effect of intensive insulin therapy for newly diagnosed type 2 diabetic patients in early time. Method Select 120 newly diagnosed type 2 diabetic patients randomly as treatment group, they were treated as intensive insulin therapy. At the same time, select another 120 newly diagnosed type 2 diabetic patients randomly as control group, they were treated by oral hypoglycemic drugs. Then, observe the changes in the fasting blood glucose(FBG), postprandial blood glucose (PBG), glycosylated hemoglobin A_1（HbAlc）, insulin level, C peptide level of the tow groups. Follow up the treatment group for one year. Result The levels of FBG、PBG and HbAlc were reduced significantly in intensive insulin therapy group. Fasting insulin level and C peptide level, postprandial insulin level and C peptide level in treatment group were higher than the control groups significantly, P＜0.01. Conclusion The effect of intensive insulin therapy were better than the control group, it did much better in control the blood glucose level, reduce the high glucose toxicity, reduce the insulin resist and making the islet cells function recovery. Key Words: type 2 diabetes, insulin, intensive insulin therapy 糖尿病已成为一种全球性的多病因的慢性非传染性流行病，是危害人类健康的主要慢性疾病之一。近年临床研究表明，对新诊断的2型糖尿病（type 2 diabete mellit，T2DM）患者进行短期胰岛素强化治疗，可使一部分患者在短时间内血糖得到控制，胰岛细胞功能得到最大限度的恢复，从而缓解T2DM患者的病情，预防糖尿病并发症发生。 1? 对象和方法