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Barriers to advancing nanotechnology to better improve and translate nanomedicines.pdf

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Barriers to advancing nanotechnology to better improve and translate nanomedicines.pdf

Front．Chem．Sci．Eng．2014，8(3)：265-275 DoI10．1007／sl1705．014．1442．x Barrierstoadvancingnanotechnologytobetterimproveand translatenanomedicines YuweiWANG，DavidW．Grainger(函) DepartmentofPharmaceuticsandPharmaceuticalChemistry,UniversityofUtah，SaltLakeCiyt,UT84112—5820，USA ◎ HigherEducationPressandSpringer-VerlagBerlinHeidelberg2014 Abstract Engineerednanomaterialsandnanotechnolo— definition or consensus on meaning currently exists． giespromisemanybeneftstoenhancebothinvitroandin Theseincludepharmaceuticalsanddrugdeliveryproducts， vivoperformance．Thisisnow manifestintheincreasing medicalimaging．theranosticsanddiagnostics．implnatable numberofreportedbiomedicalproductsunderdevelop． materials，sensorsanddevices，regenerativemedicine，and mentand testing thatcontain nanotechnologiesastheir combinationsoftechnologiescomprisingseveralofthese distinguishing perfomr ance-- enhancing components．In features into single platforms．To date．nearly 250 manycases，nano—sizedmaterialsareselectedtoprovidea nanomedicineproductsare either approved ofrhuman specific functionalaspectthatcontributesto improved use orstillin human testing seeking such regulatory medicalperfomr ance．eitherinvitroorinvivo．Nanopar— approvals[1]．Typically,nanomedicine’scontextspecifies ticlesaremostcommonly exploited in diverserolesin exploitation ofnanoscalecomponentstoenableunique topical1otionsandcreams．solubilizationaids．forinvitro technologicalorperformancegainsnotpossibleusing and invivodiagnosticandtargetingagentsinnanomedi— 1argercomponentsizes．Ofthesepossibilities．nanoparti． cines and theranostics．Despite fundamental scientific cleshavebeentheprimary initialofCUSformedicaluse． excitementand many claims to nanotechnologv—based exhibiting versatility as diagnostic and imaging tools； improvements in new biomedicalapplications，several nanoscaledrugofmr sandtargeteddurgdelivery systems； fundamentalnad