5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究有机化学.pdfVIP

2008 年第 28 卷 有 机 化 学 Vol. 28, 2008 第 6 期, 1035～1039 Chinese Journal of Organic Chemistry No. 6, 1035～1039 ·研究论文· 5-[2-(8-羟基喹啉-2-基)乙烯基]-2- 甲基-8-羟基喹啉的合成、抗氧化活性 及促进鼠骨髓间质干细胞增殖的研究 * 张培全 曾和平 (华南理工大学化学科学学院功能分子研究所 广州 510641) 摘要 设计合成了 5-[2-(8-羟基喹啉-2-基) 乙烯基]-2- 甲基-8-羟基喹啉(5), 用 IR, UV, 1H NMR, MS 和元素分析确认其结 构. 利用 DPPH•法和噻唑蓝比色法(MTT 法)分别测定了目标产物的抗氧化活性及调控鼠骨髓间质干细胞(MSCs)增殖的 作用. 结果表明, 目标产物有较强的抗氧化活性, 在低浓度时对鼠骨髓间质干细胞有促进作用. 关键词 5-[2-(8-羟基喹啉-2-基) 乙烯基]-2- 甲基-8-羟基喹啉; 抗氧化活性; 骨髓间质干细胞 Synthesis, Antioxidation Activity of 5-[2-(8-Hydroxy-quinolin-2-yl)- vinyl]-2-methyl-quinolin-8-ol and Its Induction Proliferation of Mesenchymal Stem Cells ZHANG, Pei-Quan ZENG, He-Ping* (Institute of Functional Molecules , Faculty of Chemistry, South China University of Technology, Guangzhou 510641) Abstract 5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol (5) was synthesized and charac- 1 terized by IR, UV, H NMR, MS spectra and elemental analysis. Meanwhile, the stem cell activity and anti- oxidation activity of the title compound were investigated by the MTT and DPPH• methods. From the result it can be seen that the title compound has strong antioxidation activity and can induce the proliferation of mesenchymal stem cell under a low concentration condition. Keywords 5-[2-(8-hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol; antioxidation activity; prolifera- tion of mesenchymal stem cell 自由基是生物体新陈代谢过程中产生的一类可单 和抑制脂质过氧化, 显现出巨大的潜力[6]. 最近,