4-(1H)-喹诺酮及甲氧基和溴代衍生物的合成研究有机化学.pdfVIP

DOI: 10.6023/cjoc201210031 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 4-(1H)-喹诺酮及甲氧基和溴代衍生物的合成研究 马梦林*,a,b 黄剑彪a,c 王玉良b 陈淑华b 陈 华b (a 西华大学物理与化学学院 成都 610039) (b 四川大学化学学院 教育部绿色化学重点实验室 成都 610064) (c 上海大学理学院 上海 200444) 摘要 提出了一种 4-(1H)-喹诺酮衍生物合成方法. 以 3,3-二乙氧基丙酸乙酯和苯胺为原料, 生成中间体 3-(苯基亚氨 基)丙酸乙酯, 再经热环化或微波促进环化两步反应制备 4-(1H)-喹诺酮, 并以此方法合成了 7 个溴代或甲氧基取代的 4-(1H)-喹诺酮衍生物. 关键词 4-(1H)-喹诺酮; 3,3-二乙氧基丙酸乙酯; 合成方法; 环化 Syntheses of 4-(1H)-Quinolones and the Brominated or Methoxy Substituted Derivatives Ma, Menglin*,a,c Huang, Jianbiaoa,b Wang, Yuliangc Chen, Shuhuac Chen, Huac a ( School of Physics and Chemistry, Xihua University , Chengdu 610039) b ( Key Laboratory of Green Chemistry and Technology of Ministry of Education, Faculty of Chemistry, Sichuan University, Chengdu 610064) c ( College of Science, Shanghai University, Shanghai 200444) Abstract A simple and new synthetic approach to 4-(1H)-quinolones was described. This method was started from ethyl 3,3-diethoxypropanoate and aniline via a synthetic sequence of preparation of key intermediate 3-(phenylimino)propionate and cyclization reaction. The brominated or methoxy substituted derivatives were synthesized by this new method as well. Keywords 4(1H)quinolones, 3,3-diethox