加兰他敏类生物碱的不对称合成研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201312002 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 加兰他敏类生物碱的不对称合成研究进展 王海明a 陈 鹏*,b 唐 萌*,a (a 兰州大学药学院 兰州 730000) (b 吉林大学化学学院 无机合成与制备化学国家重点实验室 长春 130012) 摘要 加兰他敏类生物碱是氢化二苯并呋喃类生物碱的重要组成部分. 它们独特的结构、良好的生物活性和前景广阔 的药用价值吸引了众多化学家和药物学家的兴趣. 其合成难点是其中的含芳基手性全碳季碳的构筑. 本综述旨在阐述 到目前为止加兰他敏类生物碱的不对称合成方法, 根据合成路线中手性季碳的构筑方式分类进行说明, 并尝试对每种 合成方法进行评述. 关键词 加兰他敏; 力可拉敏; 不对称合成; 手性全碳季碳 Progress in Asymmetric Synthesis of Galanthamine-Type Alkaloids Wang, Haiminga Chen, Peng*,b Tang, Meng*,a a ( School of Pharmacy, Lanzhou University, Lanzhou 730000) b ( State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University , Changchun 130012) Abstract Galanthamine-type alkaloids are an important type of hydrodibenzofuran alkaloids. Their unique intriguing struc- tures, significant biological activitives and pharmacological potential have attracted much attention of chemists and pharma- cologists. The major challenge for their synthesis is how to construct the aryl-substituted all-carbon quaternary stereogenic center. In this paper, current strategies for asymmetric synthesis of galanthamine-type alkaloids are reviewed, and the different methods to prepare the quaternary carbon are discussed. The features of different strategies are also commented. Keywords galanthamine; lycoramine; asymmetric synt