单萜吲哚生物碱Uleine及其衍生物的合成进展有机化学.pdfVIP

DOI: 10.6023/cjoc1108212 学术动态 有机化学 Chinese Journal of Organic Chemistry REPORT 单萜吲哚生物碱Uleine 及其衍生物的合成进展 王学军a,b 刘建利*,a 黄新炜a 王翠玲a (a 西部资源生物与现代生物技术省部共建教育部重点实验室 西北大学生命科学院 西安 710069) (b 甘肃中医学院化学教研室 兰州 730000) 摘要 生物碱 uleine 及其衍生物从结构上看属于单萜吲哚生物碱, 它们共同的结构特征是吲哚核与碱性氮原子之间只 有一个碳相隔, 而不像其它单萜吲哚生物碱有两个碳原子. 由于其结构特异, 天然含量少, 因而其合成工作一直吸引 着化学工作者. 总结 uleine 生物碱及其衍生物的合成方法, 根据构建环的种类不同, 把合成方法分为五类. 大部分方法 都是以吲哚和吡啶衍生物为起始原料进行四环的合成, 有几条合成路线简短易行. 关键词 uleine; 衍生物; 合成; 综述 Progress in the Synthesis of Indole Alkaloid Uleine and Its Derivatives Wang, Xuejuna,b Liu, Jianli*,a Huang, Xinweia Wang, Cuilinga a ( Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, Xian 710069 ) b ( Department of Chemistry, Gansu College of Traditional Chinese Medicine, Lanzhou 730000) Abstract Uleine and its derivatives belong to the monoterpenoid indole alkaloids based on their structures. The characteristic of their structures is only one carbon atom which separates the indole nucleus and the basic nitrogen atom, as opposed to the normal two-carbon bridge of tryptamine and most monoterpenoid indole alkaloids. Their natural contents are extremely low, and their synthetic work has attracted generations of chemists.