双功能二亚乙基三胺五乙酸系列配体作为磁共振成像造影剂的合成研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201310052 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 双功能二亚乙基三胺五乙酸系列配体作为磁共振成像造影剂的 合成研究进展 万福贤a 俞开潮*,b (a 山东农业大学化学与材料科学学院 泰安 271018) (b 华中科技大学化学与化工学院 武汉 430074) 摘要 二亚乙基三胺五乙酸(DTPA)及其衍生物具有优良的配位性能, 在化学及生物医学领域有广泛的应用, 尤其是作 为磁共振成像造影剂. 双功能 DTPA 类配体对于研发 DTPA 类磁共振成像造影剂具有重要的作用, 制备符合不同要求 的该类配体具有相当的难度. 着重介绍双功能 DTPA 类配体的各种合成方法, 并对不同的方法和路线优缺点进行比较. 关键词 磁共振成像(MRI); DTPA; 钆配合物; 双功能配体; 合成 Recent Progress in the Synthesis of Bifunctional Diethylenetriamine- pentaacetic Acid Derivatives Ligand for Magnetic Resonance Imaging Contrast Agent Wan, Fuxiana Yu, Kaichao*,b (a College of Chemistry and Material Science, Shan Dong Agricultural University, Taian 271018) b ( School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074) Abstract Diethylenetriaminepentaacetic acid (DTPA) and its derivatives have been used in chemistry, biology, medicine and many other fields due to their coordination properties, especially, used as magnetic resonance imaging (MRI) contrast agent. Bifunctional-DTPA ligand can be easily and readily linked to various biomolecules. It is of primary importance for the development high relaxation efficiency and/or targeted MRI contrast agents, but the synthesis of bifunctional-DTPA ligand is rather difficult. In this review, various synthetic methods for synthesizing these compounds are summ