单克隆抗体治疗自身免疫性疾病研究进展_陈镜宇.pdfVIP

Chinese Journal ofN ew Drugs 2011, 20( 8) , (安徽医科大学临床药理研究所, 抗炎免疫药理学省部共建教育部重点实验室, 抗炎免疫药物安徽省工程 术研究中心, 合肥 230032) [] 自身免疫性疾病的治疗通常采用的糖皮质激素免疫抑制剂等, 虽然有 一定疗效, 但长期使用 都会产生严重的不良反应, 而且都只能减缓病情的发展, 并不能根治疾病近 10余年来, 单克隆抗体治疗自 身免疫性疾病已成为研究热点这些单克隆抗体通过不同的机制发挥作用, 包括结合可溶性细胞因子和生 长因子, 调节受体和受体信号, 以及通过抗体介导的细胞依赖的细胞毒作用抗体介导的细胞吞噬作用补体 依赖的细胞毒作用耗竭异常的免疫细胞及介导细胞信号等研制更高效更安全给药更方便的抗体药物是 未来抗体药物的发展趋势通过改造 IgG的氨基酸序列或者对其蛋白质进行 一些修饰, 以及以多个不同的 信号途径或者致病介质为靶标的双特异性抗体, 是新型单克隆抗体药物研究的重要方向本文就治疗自身 免疫性疾病的单克隆抗体研究进展作 一综述 [] 单克隆抗体; 自身免疫性疾病; 作用机制 [] R979. 5 [] A [] 1003- 373 ( 2011) 08- 0697- 07 Research and d evelopm en t of m onoclonal an tibodies in autoimm un e diseases CHEN Jingyu, W EIW ei ( Institute of C lin ical Pharm acology, A nhu iM ed ical Un ivers ity, theK ey L aboratory of A ntiinf lammatory and Imm unop harmacology, M in istry of Education, P R , A nhui Eng ineering T echno logy Research Center of A ntiinf lamm atory and Immune D rug s, H fe e i 230032, Ch ina ) [ Abstract] A t present, glucocorticoids and mi munosuppressants are generally used in automi mune d isea ses, but they only am eliorate the severity of d iseases and can induce severe adverse reactions follow ing longterm use. In recent years, monoclonal antibod ies have been developed as main therapeutic options for automi mune. M echan isms of action of these therapeutic antibodies include comb in ing soluble cytok ines and grow th factors, regu lating receptors and receptor signals, depleting excrescent mi mune cells by antibodydependent cellmed iated cyto toxicity, antibodydependent cellular phagocytosis, complementdependent cytotoxicity, and so on. The new thera peutic antibodiesmust be effective, safe and adm inistered conveniently. In the future, research sho