吲哚与硝基烯的Friedel-Crafts反应的研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201301051 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 吲哚与硝基烯的Friedel-Crafts 反应的研究进展 王春超 谢绍雷 解正峰* (新疆大学化学化工学院 石油天然气精细化工教育部新疆维吾尔自治区重点实验室 乌鲁木齐 830046) 摘要 吲哚作为核心结构广泛存在于生物碱和药物中, 吲哚衍生物在生物体的生理活动中起着重要的作用, 其中吲哚 和硝基烯的Friedel-Crafts 是生成吲哚衍生物的重要方法. 按照反应中催化剂种类的不同分为: (1)无催化剂, (2)离子液体 催化剂, (3)金属盐催化剂, (4)配合物催化剂, (5) Brønsted 酸催化剂, (6)有机小分子催化剂, (7)其他类型催化剂. 对吲哚 与硝基烯的 Friedel-Crafts 反应的情况进行了综述. 关键词 Friedel-Crafts 反应; 吲哚; 硝基烯; 催化剂 Research Progress in Friedel-Crafts Reaction of Indoles and Nitroalkenes Wang, Chunchao Xie, Shaolei Xie, Zhengfeng* (Key Laboratory of Oil Gas Fine Chemicals, Ministry of Education Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University , Urumqi 830046) Abstract Indoles, as the core structure, exist widely in many alkaloid natural products and pharmaceuticals. The derivatives of indole play an important role in organism physiological activities. The Friedel-Crafts reaction of indoles and nitroalkenes is an important method to generate indole derivatives. According to the kinds of the catalyst in the reaction, the Friedel-Crafts reactions of indoles and nitroalkenes were summarized in this paper as follows: (1) catalyst-free, (2) ionic liquid catalyst, (3) metal salt catalyst, (4) coordination compound catalyst, (5) Brønsted acid catalyst, (6) small molecular organic catalyst, (7) other catalysts. Keywords Friedel-Crafts reaction; indole; nitroolefin; catalyst Friedel-Crafts 反应又称为傅克反应或 F-C 反应, 是