含肟醚的姜黄素衍生物的合成及生物活性研究有机化学.pdfVIP

DOI: 10.6023/cjoc201402035 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 含肟醚的姜黄素衍生物的合成及生物活性研究 陈 玉 王忠波 张 贤 夏丽娟 龚华玉 赵洪菊 薛 伟* (贵州大学精细化工研究开发中心 绿色农药与农业生物工程国家重点实验室培育基地 教育部绿色农药与生物工程重点实验室 贵阳 550025) 摘要 采用活性拼接原理, 将肟醚引入到含杂环的姜黄素衍生物 1,4-戊二烯-3-酮结构中, 合成了一系列新的 1-芳基-5- 杂环-1,4-戊二烯-3-酮肟醚类化合物, 其结构经 IR, 1H NMR, 13C NMR, ESI-MS 和元素分析确认. 初步生物活性测试结 果表明: 在药剂浓度为 500 μg/mL 时, 目标化合物具有一定的抗烟草病毒(TMV)活性. 关键词 姜黄素; 肟醚; 合成; 抗 TMV 活性 Synthesis and Biological Activity of Oxime Ethers of Curcumin Derivatives Chen, Yu Wang, Zhongbo Zhang, Xian Xia, Lijuan Gong, Huayu Zhao, Hongju Xue, Wei* (State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering , Key Laboratory of Green Pesticide and Bioengineering of Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025) Abstract On the principle of biologically active factor splicing, curcumin derivatives introduced active functional group oxime ethers into the structure of 1,4-pentadien-3-one. A series of new 1-phenyl-5-heterocycle-1,4-pentadien-3-one oxime ethers were synthesized, and their structures were identified by IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis. The preliminary bioassay results indicated that target compounds showed certain antiviral activity against