基于缺电子烯胺交叉氨化过程的多组分反应研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201312016 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 基于缺电子烯胺交叉氨化过程的多组分反应研究进展 曹 硕a 景艳锋a 刘云云a,b 万结平*,a,b (a 江西师范大学化学化工学院 南昌 330022) (b 教育部功能有机小分子重点实验室 江西师范大学 南昌 330022) 摘要 缺电子烯胺结构上含有多个不同活性的亲核和亲电反应位点, 同时双键本身可以作为烯键给予体参与反应, 因 此可以通过各种亲核、亲电以及环加成等转化广泛应用于有机合成反应. 综述结合我们自己小组的研究工作和兴趣, 对基于缺电子烯胺如烯胺酮、烯胺酯等和含胺基试剂包括铵、胺、烯胺、脲和硫脲等之间的交叉氨化为关键转化, 并 和其它底物发生串联转化的多组分反应研究进展进行了总结. 关键词 缺电子烯胺; 交叉氨化; 多组分反应; 杂环 Recent Advances on Multicomponent Reactions Based on the Transamination Process of Electron Deficient Enamines Cao, Shuoa Jing, Yanfenga Liu, Yunyuna,b Wan, Jieping*,a,b (a College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022) b ( Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Normal University , Nanchang 330022) Abstract Electron deficient enamines bear several different nucleophilic and eletrophilic sites in their structures, they can also serve as donors of C ＝C bonds in organic reactions. Therefore, electron deficient enamines have been broadly employed in organic synthesis via various nucleophilic, electrophilic transformation and cycloaddition. Based on the research interest and works of our group in the chemistry of electron deficient enamines, the research advances on multicomponent reactions (MCRs) are reviewed based on the transaminati