基于多米诺反应合成吲哚衍生物有机化学.pdfVIP

DOI: 10.6023/cjoc201403015 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 基于多米诺反应合成吲哚衍生物 冯亚栋 张 红 程国林* 崔秀灵* (分子药物教育部工程研究中心 厦门市海洋与基因工程药物重点实验室 华侨大学分子药物学研究所 厦门 361021) 摘要 近年来, 多米诺反应作为合成吲哚衍生物的有效方法已得到有机合成化学家的广泛关注. 该反应过程中, 不需 改变反应条件和添加试剂, 中间体也无需分离和提纯, 实现了原子经济和环境友好的目标. 通过过渡金属催化的多米 诺反应合成吲哚衍生物, 已经得到了深入研究并成为一种构筑该类杂环的有利工具. 重点综述了近年来运用金属催化 多米诺反应合成吲哚及其衍生物方面的研究进展, 以催化剂的类型进行分类, 介绍相关反应的特点和优势. 关键词 多米诺反应; 金属催化; 吲哚衍生物; 合成 Synthesis of Indole Derivatives via Domino Reactions Feng, Yadong Zhang, Hong Cheng, Guolin* Cui, Xiuling* (Engineering Research Center of Molecular Medicine, Ministry of Education, Xiamen Key Laboratory of Marine and Gene Drugs, Institutes of Molecular Medicine, Huaqiao University, Xiamen 361021) Abstract Domino reactions have received great attentions of organic chemist as an efficient protocol to synthesize indole derivatives. In this process, it is not required isolating or purifying the intermediates, changing the reaction condition and add- ing reagents. Transition metal-catalyzed domino reactions to synthesize indole derivatives have already been widely studied and become a powerful tool. In this paper, the progress of recent domino reactions applied to construct indole and its deriva- tives is reviewed, focusing on the transition metal-catalyzed domino reactions, and detailed analysis on the versatility and ap- plications. Keywords domino reactions; metal catalysis; indole derivatives; synthesis 吲哚普遍存在于天然产物和