末端炔烃二聚反应合成共轭烯炔的研究进展有机化学.pdfVIP

2007 年第 27 卷 有 机 化 学 Vol. 27, 2007 第 7 期, 1078～1086 Chinese Journal of Organic Chemistry No. 7, 1078～1086 ·综述与进展· 末端炔烃二聚反应合成共轭烯炔的研究进展 陶李明 a,b 梁 云 a,b 李金恒*,a a ( 湖南师范大学化学化工学院化学生物学与中药分析教育部重点实验室 长沙 410081) (b 湘南学院化学与生命科学系 郴 423000) 摘要 综述了不同催化体系催化末端炔烃二聚反应合成共轭烯炔化合物的研究进展. 其中催化体系主要包括过渡金属 配合物、镧系和锕系金属配合物、第三主族元素配合物以及有机催化剂. 实验结果表明: 不同催化体系对末端炔烃二 聚反应的选择性控制有影响, 尤其是区域选择性(头-头二聚或头-尾二聚). 关键词 末端炔烃; 二聚反应; 烯炔化合物; 选择性 Progress in Dimerizations of Terminal Alkynes to Synthesize Enynes TAO, Li-Minga,b LIANG, Yuna,b LI, Jin-Heng*,a a ( Key Laboratory of Chemical Biology Traditional Chinese Medicine Research of Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081) b ( Department of Chemistry and Life Science, Xiangnan University, Chenzhou 423000) Abstract Progress in a variety of catalytic systems-catalyzed dimerizations of terminal alkynes to synthe- size enynes is summarized. These catalytic systems included transition-metal complexes, organolanthanide and organoactinium complexes, IIIA element complexes and organic catalysts. The results showed that the catalytic systems had a fundamental influence on the selectivity, in particular regioselectivity (head-to- head or head-to-tail), of the dimerization reactions of terminal alkynes. Keywords terminal alkyne; dimerization reaction; enyne; selectivity 共轭烯炔是指分子中同时含有两个相互共轭的双 的烯炔混合物(Scheme 1a); (2)末端炔烃通过与