环状磷酸催化合成2-取代苯并咪唑有机化学.pdfVIP

DOI: 10.6023/cjoc201205006 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 环状磷酸催化合成2-取代苯并咪唑 王湘波a 简腾跃b 马晓伟a 何 林*,a (a 石河子大学化学化工学院 新疆兵团化工绿色过程重点实验室-省部共建国家重点实验室培育基地 石河子 832000) (b 中国科学院化学研究所 北京分子科学国家实验室 中国科学院分子识别与功能重点实验室 北京 100190) 摘要 以邻苯二胺和醛为原料, 四氢呋喃为溶剂, 在环状磷酸催化下, 室温下合成了一系列2-取代苯并咪唑化合物. 考 察了催化剂种类、用量和溶剂对反应的影响, 确定了最优反应条件, 提出了可能的反应机理. 该反应具有操作简单, 条 件温和, 产率高及环境友好等优点. 关键词 邻苯二胺; 醛; 环状磷酸; 苯并咪唑 Synthesis of 2-Substituted Benzimidazoles Catalyzed by Cyclic Phosphoric Acid Wang, Xiangboa Jian, Tengyueb Ma, Xiaoweia He, Lin*,a a ( Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000) b ( National Laboratory for Molecular Sciences, Chinese Academy of Sciences Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190) Abstract In the presence of cyclic phosphoric acid, a series of 2-substituted benzimidazoles were synthesized by the reaction of o-phenylenediamine and aldehyde in tetrahydrofuran at room temperature. The influence of different catalysts, catalyst amount and solvent were investigated, the optimal reaction conditions were obtained and a possible mechanism was