碱性条件下4(3H)-喹唑啉酮的一锅合成有机化学.pdfVIP

DOI: 10.6023/cjoc1108102 研究论文 有机化学 Chinese Journal of Organic Chemistry ARTICLE 碱性条件下4(3H)-喹唑啉酮的一锅合成 刘长娥a 于琪瑶b 唐健红a,c 李加荣*,a (a 北京理工大学化工与环境学院 北京 100081) (b 北京理工大学化学学院 北京 100081) (c 华侨大学化工学院 厦门 362021) 摘要 研究了一种碱性条件下由邻氨基芳香腈 1 与醛 2 一锅合成 4(3H)-喹唑啉酮 3 的新方法. 反应经由亲核加成、分 子内的 Pinner 关环、Dimroth 重排和氧化脱氢串联转化而成. 产物结构经 1H NMR, 13C NMR, IR 和元素分析确证. 关键词 一锅合成; 邻氨基芳香腈; 醛; 碱催化; 4(3H)-喹唑啉酮 One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition Liu, Changea Yu, Qiyaob Tang, Jianhonga,c Li, Jiarong*,a a ( School of Chemical Engineering and Environment, Beijing Institude of Technology, Beijjing 100081) b ( School of Chemistry, Beijing Institude of Technology, Beijjing 100081) c ( College of Chemical Engineering, Huaqiao University, Xiamen 362021) Abstract A series of 4(3H)-quinazolinones 3 were obtained from the one-pot synthesis of available substituted aromatic o-aminonitriles 1 with aldehydes 2 in the present of base. This tandem transformation was included in addition, intramolecular Pinner reaction, Dimroth rearrangement and oxidative dehydrogenation. The structures of products were characterized by 1H NMR, 13C NMR, IR spectra and elemental analysis. Keywords one-pot synthesis; aromatic o-aminonitrile; aldehyde; base catalysis; 4(3H)-quinazolinone 4(3H)-喹唑啉酮类化合物是一类重