苯并咪唑类化合物的合成方法进展有机化学.pdfVIP

DOI: 10.6023/cjoc201310012 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 苯并咪唑类化合物的合成方法进展 朱观明a 杨柳阳a 崔冬梅*,a (浙江工业大学药学院 杭州 310014) 摘要 苯并咪唑类化合物具有抗 HIV-1 、抗肿瘤、抗细胞增殖、抗寄生虫、抗炎症、抗氧化和抗癫痫方面的生物活性, 因此这类化合物的合成备受化学家们的关注. 首次按照反应中间体将近 5 年合成这类化合物的方法分为以 N-亚甲基邻 苯二胺(或 N-亚甲基邻硝基苯胺)为中间体, 以 N-酰基邻苯二胺为中间体和以芳基脒(胍)为中间体三类. 通过从这个角 度论述这些合成方法, 期望能够为设计出更好的合成方法提供启发. 关键词 苯并咪唑; N-亚甲基邻苯二胺; N-亚甲基邻硝基苯胺; N-酰基邻苯二胺; 芳基脒(胍); 催化剂 Advances in the Synthetic Methods of Benzimidazoles Zhu, Guanminga Yang, Liuyanga Cui, Dongmei*,a (College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014) Abstract Benzimidazoles possess various bioactivities, such as anti-HIV-I, antineoplastic, antiproliferation, antiparasitic and so on, hence the synthetic methods of this class of compounds have attracted much attention. In order to provide some inspira- tion of better synthetic method design, in this review these methods reported during past five years will be firstly classified into three types according to the reaction intermediates, namely N-methene o-diaminobenzene (or N-methene-o-nitroaniline), N-acyl o-diaminobenzenes and arylamidine (aryl guanidine). Keywords benzimidazole; N-methene o-diaminobenzene; N-methene-o-nitroaniline; N-acyl o-diaminobenzene; aryl amidine (aryl guanidine); catalyst [14] [15] 含有苯并咪唑环结构单元的化合物在抗 HIV-1 病 法的某方面问题. 比如毛郑州 和 Chawla 等 论述了 [1] [2] [3] [4]