铜催化水相Ullmann类型偶联反应研究进展有机化学.pdfVIP

DOI: 10.6023/cjoc201301037 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 铜催化水相Ullmann 类型偶联反应研究进展 李正凯a 吴之清a 邓 杭a 周向葛*,a,b (a 四川大学化学学院 成都 610064) (b 苏州大学材料与化学化工学院 有机合成江苏省重点实验室 苏州 215123) 摘要 铜催化的 Ullmann 类型交叉偶联反应是有机合成中重要的合成方法. 与通常有机反应中采用的有机溶剂相比, 利用自然界储量丰富、廉价、绿色环保的水作为有机反应介质更符合当前所倡导的“绿色”化学和低碳可持续发展的 要求. 综述了最近几年来水相铜催化的包括 C—N, C—O, C—S 和 C—C 等Ullmann 类型交叉偶联反应的最新研究进展. 关键词 铜; 催化; 水; Ullmann 偶联反应; 绿色化学 Progress in Copper-Catalyzed Ullmann-Type Coupling Reactions in Water Li, Zhengkaia Wu, Zhiqinga Deng, Hanga Zhou, Xiangge*,a,b (a College of Chemistry, Sichuan University, Chengdu 610064) b ( Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science , Soochow University, Suzhou 215123) Abstract Copper-catalyzed Ullmann-type coupling reactions have become an important powerful synthetic method in mod- ern organic synthesis. Compared with the usually used organic solvent, employing abundant, cheap, environmental-friendly water as reaction media is obviously more fitful for green chemistry and low carbon sustainable development. The recent pro- gress of copper-catalyzed Ullmann-type including C—N, C—O, C—S and C—C coupling reactions by using water as solvent is reviewed. Keywords copper; catalysis; water; Ullmann coupling reaction; green chemistry 近几十年来, 过渡金属催化的交叉偶联反应一直是 Ullmann 等[5]应用到 C—C 偶联反应中(Eq. 1). 目前, 铜 有机化学的研究热点,