铜催化碳-杂原子双键不对称硅氢加成反应的研究进展有机化学.pdfVIP

2008 年第 28 卷 有 机 化 学 Vol. 28, 2008 第 5 期, 761～767 Chinese Journal of Organic Chemistry No. 5, 761～767 ·综述与进展· 铜催化碳-杂原子双键不对称硅氢加成反应的研究进展 * * 陈玲珍 彭家建 厉嘉云 白 赢 邱化玉 来国桥 (杭州师范大学有机硅化学及材料技术教育部重点实验室 杭州 310012) 摘要 总结了近二十年来铜催化碳-杂原子双键不对称硅氢加成的研究近展, 概括了手性铜配合物催化体系催化简单 酮﹑α,β -不饱和酮酯和亚胺的不对称硅氢加成, 并阐述了不对称硅氢加成的催化机理. 关键词 手性铜配合物; 不对称硅氢加成; 酮类化合物; 机理 Progress in Asymmetric Hydrosilylation of Carbon-Heteroatom Unsaturated Double Bond Compounds by Copper Catalyst CHEN, Ling-Zhen PENG, Jia-Jian LI, Jia-Yun BAI, Ying QIU, Hua-Yu* LAI, Guo-Qiao* (Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012) Abstract The recent advances in asymmetric hydrosilylation of carbon-heteroatom unsaturated double bond compounds by copper catalysts were summarized. The performances of a variety of different substrates which were catalyzed by the combination of copper complexes and chiral ligand were analyzed. The possi- ble mechanisms of asymmetric hydrosilylation were also discussed. Keywords copper complex; asymmetric hydrosilylation; ketone; mechanism 通过潜手性 C ＝X (X ＝O, N)双键的不对称氢化产 亚胺等碳-杂原子双键的硅氢加成反应具有高活性和选 生手性碳原子, 是一个技术和经济上都可行的方法, 是 择性 . 特别是新颖且价格低廉的铜手性催化体系的发 合成生物活性分子的重要方法[1～3]. 不对称硅氢化是不 展, 大大拓宽了此类非贵金属催化剂的应用前景. 在近 对称加氢的重要方法之一, 其主要的优点是条件温和、 20 年间, 铜配合物催化碳-杂原子双键不对称硅氢加成 无需耐高压技术、可操作性强.