Genetic Influence of Candidate Osteoporosis Genes in Saudi Arabian Population A Pilot Study.pdfVIP

Hindawi Publishing Corporation Journal of Osteoporosis Volume 2012, Article ID 569145, 5 pages doi:10.1155/2012/569145 Clinical Study Genetic Influence of Candidate Osteoporosis Genes in Saudi Arabian Population: A Pilot Study Mir Sadat-Ali1 and Haifa A. Al-Turki2 1 Department of Orthopaedic Surgery, College of Medicine, University of Dammam and King Fahd University Hospital, AlKhobar 31952, Saudi Arabia 2 Department of Obstetrics and Gynecology, College of Medicine, University of Dammam and King Fahd University Hospital, AlKhobar 31952, Saudi Arabia Correspondence should be addressed to Mir Sadat-Ali, drsadat@ Received 6 December 2011; Revised 20 January 2012; Accepted 25 January 2012 Academic Editor: Jun Iwamoto Copyright © 2012 M. Sadat-Ali and H. A. Al-Turki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background and Objectives. The purpose of the present study is to find the genes and SNP that influence BMD and postmenopausal Saudi women. Material and Methods. Two-hundred ethnic Saudi Arabian women with a diagnosis of postmenopausal osteoporosis were the subjects of this study. Baseline blood hematology, biochemistry, and bone panel were done. Blood was collected, and three TaqMan-MGB probes were used to analyze SNP variants in ALOX15 (rs7220870), LRP5 (C10), and TNFRSF11B (C10). Results. The variant of ALOX15 17p13 showed that the BMD of the spine was lower in the AA allele (P value 0.002) and fractures were highest at 50% compared to CC allele. In the TNFRSF11B gene, BMD of the hip and spine was significantly higher in the GG allele and the h