Genetic Study of Propoxur Resistance—A Carbamate Insecticide in the Malaria Mosquito, Anopheles stephensi Liston.pdfVIP

SAGE-Hindawi Access to Research Malaria Research and Treatment Volume 2010, Article ID 502824, 6 pages doi:10.4061/2010/502824 Research Article Genetic Study of Propoxur Resistance—A Carbamate Insecticide in the Malaria Mosquito, Anopheles stephensi Liston D. Sanil1 and N. J. Shetty1, 2 1 Centre for Applied Genetics, Bangalore University, J. B. Campus, Bangalore 560 056, India 2 Janardhana Foundation, Nagadevanahalli, Jnanabharathi Post, Bangalore 560 056, India Correspondence should be addressed to N. J. Shetty, shetty nj@yahoo.co.in Received 1 October 2010; Accepted 22 December 2010 Academic Editor: Charles Wondji Copyright © 2010 D. Sanil and N. J. Shetty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Anopheles stephensi Liston (Diptera: Culicidae) is the urban vector of malaria in the Indian subcontinent and several countries of the Middle East. The genetics of propoxur resistance (pr ) in An. stephensi larvae was studied to determine its mode of inheritance. A diagnostic dose of 0.01 mg/L as recommended by WHO was used to establish homozygous resistant and susceptible strains. Reciprocal crosses between the resistant and susceptible strains showed an F1 generation of incomplete dominance. The progenies of backcrosses to susceptible parents were in 1 : 1 ratio of the same phenotypes as the parents and hybrids involved. The dosage mortality (d-m) lines were constructed for each one of the crosses, and the degree of dominance was calculated. It is concluded that propoxur resistance in An. stephensi larvae is due to monofactorial inheritance with incomplete dominance and is autosomal in natu