live attenuated versus inactivated influenza vaccine in.pdfVIP

T h e n e w e ng l a nd j o u r na l o f m e dic i n e original article Live Attenuated versus Inactivated Influenza Vaccine in Infants and Young Children Robert B. Belshe, M.D., Kathryn M. Edwards, M.D., Timo Vesikari, M.D., Steven V. Black, M.D., Robert E. Walker, M.D., Micki Hultquist, M.S., George Kemble, Ph.D., and Edward M. Connor, M.D., for the CAIV-T Comparative Efficacy Study Group* A BS TR AC T Background Universal vaccination of children 6 to 59 months of age with trivalent inactivated From the Saint Louis University Health influenza vaccine has recently been recommended by U.S. advisory bodies. To eval- Sciences Center, St. Louis (R.B.B.); Vander- bilt University School of Medicine, Nash- uate alternative vaccine approaches, we compared the safety and efficacy of intra- ville (K.M.E.); University of Tampere Medi- nasally administered live attenuated influenza vaccine with those of inactivated vac- cal School, Tampere, Finland (T.V.); Kaiser cine in infants and young children. Permanente Vaccine Study Center, Oakland, CA (S.V.B.); and MedImmune, Gaithers- burg, MD (R.E.W., M.H., G.K., E.M.C.). Ad- Methods dress reprint requests to Dr. Belshe at the Children 6 to 59 months of age, without a recent episode of wheezing illness or