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P E r S P E c t i v E S
117. Yi, C. X. et al. Ventromedial arcuate nucleus Acknowledgements functional and structural changes in the
communicates peripheral metabolic information to the The work is supported by the National Institute for Health 6
suprachiasmatic nucleus. Endocrinology 147, Research (NIHR). Biomedical Research Centre, Oxford, UK, auditory system . For example, compared
283–294 (2006). and The Wellcome Trust, London, UK. We would like to thank to non-musicians, pianists show increased
118. Malek, Z. S., Sage, D., Pevet, P. Raison, S. Daily G. Goodwin (head of the Department of Psychiatry, University
rhythm of tryptophan hydroxylase‑2 messenger of Oxford, UK), C. Kennard (head of the Department of neural activity (measured by magnetic source
ribonucleic acid within raphe neurons is induced by Clinical Neurology, University of Oxford, UK), K. Porcheret imaging) in the auditory cortex in response
corticoid daily surge and modulated by enhanced (Nuffield Laboratory of Ophthalmology, University of Oxford, 7
locomotor activity. Endocrinology 148, 5165–5172 UK), K. Davies and P. Oliver (Medical Research Council to hearing piano notes . The strength of
(2007). Functional Genomics Unit, University of Oxford, UK) for their neuronal activation to piano notes was
119. He, Y. et al. The transcriptional repressor DEC2 valuable input during the preparation of this manuscript.
regulates sleep length in mammals. Science 325, found to correlate with the age at which
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