异基因小鼠胸腺胞微囊移植治疗红斑狼疮的实验研究.pdf

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异基因小鼠胸腺胞微囊移植治疗红斑狼疮的实验研究.pdf

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异基因小鼠胸腺胞微囊移植治疗红斑狼疮的实验研究

II Abstract Objective:To elucidate the therapeutic effects of allograft thymocytes micro- encapsulated with agarose transplanted into systemic lupus erythematosus(SLE) mice. Methods: 35 Babl/cC BL/6 F mice were equally divided into 5 groups at random 57 1 after their being injected with their parental lymphocytes suspended solution. When the SLE models were constructed successfully, group A accepted a therapy by physiological saline combined with hollow microencapsulations; Group B accepted a therapy by adrenaline combined with hollow micoencapsulations; Group C physiological saline and microencapsulated thymocytes; Group D adrenaline and microencapsulated thymocytes; Group E physiological saline and suspended thymocytes solution. 25 days after the therapies, mice serum were detected by flow cytometry(FCM) for T cells’ ratio of + + CD4 /CD8 ; Thymus were weighed with an electronic