原创力文档a psa pyramid for men with initial prostate-specific antigen ≤3 ngml a plea for individualized prostate cancer screening：一个男人最初的前列腺特异性抗原≤3 ngml一个性化筛选前列腺癌psa金字塔抗辩.pdfVIP
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a psa pyramid for men with initial prostate-specific antigen ≤3 ngml a plea for individualized prostate cancer screening：一个男人最初的前列腺特异性抗原≤3 ngml一个性化筛选前列腺癌psa金字塔抗辩
E U R O P E A N U R O L O G Y 6 8 ( 2 0 1 5 ) 5 9 1 – 5 9 7
ava ilable at
journal homepage: www.eu
Platinum Priority – Prostate Cancer
Editorial by Daniel D. Sjoberg on pp. 598–599 of this issue
A ‘‘PSA Pyramid’’ for Men with Initial Prostate-specific Antigen
=3 ng/ml: A Plea for Individualized Prostate Cancer Screening
Marco Randazzo a, *, Josef Beatrice a, Andreas Huber b, Rainer Grobholz c, Lukas Manka d,
Felix K. Chun e, Franz Recker a, Maciej Kwiatkowski a,d
a Department of Urology, Cantonal Hospital Aarau, Aarau, Switzerland; b Department of Laboratory Medicine, Cantonal Hospital Aarau, Aarau, Switzerland;
c Department of Pathology, Cantonal Hospital Aarau, Aarau, Switzerland; d Department of Urology, Academic Hospital Braunschweig, Braunschweig,
Germany; e Department of Urology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Article info Abstract
Article history: Background: In daily routine business, various prostate-specific antigen (PSA) retest
Accepted April 9, 2014 strategies are being promoted.
Published online ahead of Objective: To investigate rescreening intervals according to baseline PSA 3 ng/ml
stratified by any and aggressive prostate cancer (PCa).
print on April 18, 2014 Design, setting, and participants: From 1998 to 2012, data from 4350 men aged 55–70 yr
were analyzed from a population-based prospective screening study (median follow-
Keywords: up: 11.6 yr).
Early detection Outcome measurements and statistical analysis: The primary end point was detection
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