不同药物预防全麻醉后寒战效能的meta分析.pdfVIP

used：“drug, general anesthesia and shiver or rigor”，and manual or computer retrieval related magazines. Inclusion criteria and Exclusion criteria were formulated strictly as required，all Articles in connection with various drugs in preventing shiver after general anesthesia were inclusion ，more then two related articles obtained were provide a meta 一 analysis. Randomized clinical trial(RCT)would be assessed for qualities according to the Jadad scale and the concealment of treatment allocation. The trial design, Participant, type of intercention and outcome measurement in the obtained articles, where the Number of the articles was more than 2 pieces on one specific agent, were independently assessed by two reviewers. The Revman5.2 software was used to review management and analysis. The results were expressed as odds ratio(OR)and confidence internals (CI) for dichotomous outcomes, and forest plot was obtained.I40% and P0.1 were used to indicate heterogeneity and the funnel plot And fale-safe number to assess bias. The sensitivity analyze were carried out According to characteristics of the studies involved. Results: A total of 39 articles were finalized identified according to the search criteria and 26 articles were included in the Meta-analysis. The methodological quality of the articles was relatively high. Parecoxib(OR=0.14, 95%CI 0.04-0.54) tramadol (OR=0.13,95%CI 0.08-0.22) 、dexmedetomidine （OR=0.13,95%CI 0.09-0.21）、clodine were found to have a protective against shiver after general anesthesia.The reaserch made a subgroup analysis of the include study according to intervention time.The results showed that giving tramadol after the surgery （OR=0.16, 95%CI 0.06-0.44）or before the anesthesia induction (OR=0.04,95%CI 0.01-0.13) both