肿瘤标志物cecam1、muc4、ca199、ca242对胰腺癌的诊断价值研究.pdf

。 中 文 摘 要 CAl9—9和CA242两种临床常规应用胰腺癌肿瘤标志物结果进行对比。方法收集南 MUC4的截断值并计算ROC曲线下面积。根据肿瘤标志物诊断效率评估表评价各个肿 瘤标志物对胰腺癌诊断效率。采用Pearson等级相关分析判断胰腺癌组血清中 CEACAMI、MUC4、CAl9—9和CA242之间的相关性。结果①在胰腺癌病人中， 清值和阳性率与慢性胰腺炎组及对照组比较有显著升高 P 0．05 ，而慢性胰腺炎组与 90． MUC4、CAl9-9和CA242，敏感性：CEACAMl+MUC4 0％、CEACAMl+CA力轮92．0％、MUC4+ A19—992．O％、MUC．4+CA2．4288．0％、 CEACAMI+MUCA+CAl9—9 96．O％、CEACAMI+MUC4+CA24294．0％；特异性： CEACAMI+MUC4 92．0％、CEACAMI+CAl9—964．0％、CEACAMI+CA24274．O％、 9 囱蓥直匿堂睦亟±班塞生堂焦迨塞 垫!Q生2 MUC4+CAl9-9 90．0％、MUCA．+CA242 92．0％、 CEACAMl+MUCA+CA242 工具；同时MUC4．的检测可作为鉴别胰腺癌和慢性胰腺炎的一个重要参考指标。③ 选的联检组合方式，能提高对胰腺癌的诊断效率。 CEACAMlMUCACAl9—9 关键词 CA242胰腺癌诊断 o The of Levels ValueSerum of Diagnostic CEACAMl， andCA242inPatients研thPancreaticCancer MUC4，CAl99 Abstract To of Objective the valueserumlevelsof and invesdgatediagnostic CEACANl，IVIUC4 to withthetwoCOmlllOlltumorma／kel8CAl9-9andCA242inthes锄e compare pancreatic cancer Selects50 with with patient．Methods chronic patierltspancreaticcancel，50patients and30 2008to in donorsfrom October2009 panereatitisheatthr January l、lanFang hospital， andtheftrst of of ZlauJianghospital FoShan．SerumlevelsCEACAMlandIVIUCAwe您 hospital measured linked immunosorbent cut—offvltluesandareauno byenzyme assay ELISA ．The der CEACANlandblUC4wereobtainedreceiver curve AUC of by characteristic operating rtoc cunre．The of tlllTlOrlllal-kerto cancerwas鹊- diagnosticeffleieneyevery pancreatic sessed thefourfoldtableoftumormarker8．There]atiollsbetweenseruIn by CEACAMl，blUC， in CAl9-9andCA242 caltl !erw鹳detectedPearsonCOITelatiOlll pallcrlP．,atic using assay．Re- in leveland rateofCEACAMl cancer Welte sults i Sert,m positive pancreatic patientshighel than thatinchronic andnormalcontrol was panereadds patients difference and sig．ifieant betweenchronic normaleonlxolaswell P 0． panereatitispatients ofI-IUC4in leveland rate caltlCer were than 05 ．②Serm positive pancreaticpatientshigher thatinchronic andnormalcontrol therewasnO panereadtispatients obviously P 0．05 ，and differencebetw