三阴性乳腺癌临病理特征(CK56)与中医辨证分型的相关性研究.pdfVIP

关系数2.416），提示越是绝经前的TNBC患者，辨证分型为肝郁痰凝证的比率越大； 淋巴结状态与正虚毒炽证的相关性有统计学意义 P 0.05 : 淋巴结状态与正虚毒炽 证呈负相关 相关系数-1.754 ，提示淋巴结状态越好，辨证分型为正虚毒炽证的比率 越小，而淋巴结状态越差，辨证分型为正虚毒炽证的比率越大。 4、三阴性乳腺癌中医辨证分型与CK5/6表达有统计学意义 P 0.006 , 肝郁痰凝 证患者CK5/6表达多处于阴性和弱阳性表达（占78.9%），正虚毒炽证患者多处于阳 性和强阳性（占100%）。肝郁痰凝证与正虚毒炽证在CK5/6表达中的差异有统计学意 义 P 0.005 ，正虚毒炽证患者CK5/6无阴性表达，肝郁痰凝证患者CK5/6无强阳性 表达。CK5/6与正虚毒炽证呈正相关，相关系数19.270，提示CK5/6的表达越好，辨 证分型为正虚毒炽证的比率越大。 结论: 三阴性乳腺癌的中医证型在绝经前以为肝郁痰凝证为主，在绝经后以冲任 失调证和正虚毒炽证为主，正虚毒炽证淋巴结转移率比率高于其他证型，正虚毒炽证 CK5/6表达高于其他证型。月经状态、淋巴结状态及CK5/6表达可以分别作为肝郁痰 凝证和正虚毒炽证辨证的客观化指标，其他指标能否作为TNBC中医客观化的依据还 需要进一步前瞻性、大样本研究的结果。 关键词 乳腺癌;三阴;临床病理特征;中医辨证分型;相关性研究 Biological characteristics of triple negative breast cancer CK5 / 6 and the relationship between TCM syndrome research Speciality：Surgery of TCM Author ：Yang Chunrui Tutor：Archiater Yang Yi Abstract Objective: Of triple negative breast cancer pathology, molecular biology of indications CK5 / 6 in traditional Chinese medicine syndromes in the expression and the differences between the syndromes for the triple negative type of breast cancer to provide TCM objective indicators. Research method: Collected from July 2006 to December 2010 Affiliated Hospital of Shandong University of Traditional Chinese Medicine Breast thyroid surgery were treated with complete medical records, confirmed by pathology in 30 patients with triple negative breast cancer, retrospective analysis of clinical and pathological features of patients, according to countries Drug Administration issued in 1994, Chinese disease efficacy standards to TCM syndrome of breast cancer into liver Tanning card, red card of any disorder, are three sets of virtual card Chi toxic syndrome, a variety of clinical pathology indicators in the traditional Chinese medicine syndromes in the expression of the situation and differences between the syndromes were analyzed in control, the use of statistical