氟对大鼠脑细胞损害与机理及硒锌对氟的拮抗作用研究.pdfVIP

并且DNA损伤极可能是细胞凋亡的诱发因素。p53能够识别DNA损伤信 号，通过其水平上升及活性升高促进或抑制凋亡相关基因，如Bax、Fas 或Bcl．2的表达，从而启动凋亡。此外氟对细胞的凋亡诱导作用还涉及到 细胞内信号传导系统，具体说来，可在体内激活PKA和PKC，使得细胞 内游离钙离子浓度升高。上述信号传导途径的变化可进而激活内源性核酸 内切酶、促进AP一1的生成以及激活caspase而导致细胞凋亡的发生。对 于氟的上述不良影响，硒锌对其具有拮抗作用。“ ‘ 关键词：氟 硒 锌 脑细胞DNA损伤。凋亡 PKACa“PKC p53 兰主釜釜查耋尽量量耋堡 一——』墼型墼竖i￡耋 inrats andmechanisms Fluoride-induced onthe Studies impairments seleniumandzinc of and effects brainthe antagonism Abstract iSoneoftheessential could Fluorine microelements，which seriously of when anumber orsystemsuptakenexcessivelybyliving damage organs studiesshowedthatfluoridecaused inrat beings．Recent pathologicaldamage itWaSalsofoundthat concentrationfluoridein water brain，and high drinking in from couldaffectthelevelof childrenseveral intelligencedevelopment wasundertakentoelucidate epidemicinvestigations．Thepresentstudy andits to scientificbasisto fluoride-neurotoxicitymechamism，and provide the of andzinc main of selenium fluoride．Thecontentsthis application against