柔筋方对紧张型痛血管舒缩功能影响的临床与实验研究.pdfVIP

膜潜伏期较模型组降低，柔筋方可以降低紧张型头痛模型大鼠头区肌肉筋膜的敏感 性。 （5 ）柔筋方临床治疗的总有效率为86.67%，明显改善头痛指数。 结论：（1） NO 与紧张型头痛的发病密切相关，ET 可能与紧张型头痛的发病有 关联，二者可能通过影响血管的舒缩功能障碍，影响头区肌肉和皮肤的痛阈值及头区 肌筋膜痛敏感性来参与紧张型头痛的发作。 （2 ）柔筋方汤剂能有效解除或缓解头痛，改善患者的临床症状，疗效确切。柔 筋方汤能调节体内血浆 NO 、ET 的含量，调节血管的舒缩功能可能是其对紧张型头 痛发挥作用的机制之一。 关键词 柔筋方；紧张型头痛；一氧化氮/ 内皮素；血管舒缩功能 Clinical and Experimental Research on the vasomotor function of TTH interfered by Roujinfang Tang Speciality：Internal Medicine of TCM Author ：Xie Lidong Tutor：Chief physician Hu Zhiqiang Abstract Objective：By measuring vasodilator substance NO and the contraction of vascular material content of ET of tension-type headache （Tension-type headache，TTH ） model in rat plasma, brain homogenate and tension-type headache in patients ， by this we can explore the relationship of vasomotor function with TTH; while explore Roujin Decoction on the TTH of the impact of the Vasomotor function function. Methods ：（1）Animal experiments ：divide healthy Wister animals into three groups by random ：Control group （injected by saline in the neck ）；Model group （injected by ATP in the neck ）；Roujinfang group （injected by ATP in the neck and gavaged by Roujinfang Tang ）.Modeling method is both semisinal neck intramuscular injections of ATP. After the test，detect the plasma NO/ET levels with blood from abdominal vein of all rats.Make 10% brain homogenate from the left brain to detect the NO/ET levels. Clinical trials：Select 30 patients with CTTH gived Roujinfang Tang，detect the plasma NO/ET levels before and treatment （March 2012-december 2012 ）.Observe clinical efficacy of Roujinfang Tang. Results ：（1）The plasma and brain homogenate NO of rats model of Tension-type headache increase abnormally （compared with the control group，p ＜0.01 ）.Roujinfang Tang can