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补肾法对肾阴虚孕症患者着床期内膜h19表达的影响
Effect of kindey invigoration on the expression H19 in endometrium
during implantation in the kidney yin-deficiency infertility patients
Speciality:Endometriosis,Gynecology
Tutor:Prof. Lian Fang
Author:Bai Yaping
Abstract
Objective :To investgate the effection of kidney-nourishing therapy to kidney-yin
deficiency patients’ gene expression of H19 in embryonic implantation period,and explore
the curative effect mechanism of the Erzhi Tiangui granules of kidney-nourishing therapy
in improving the Resultant of In Vitro Fertilization.
Method :66 cases of infertility patients according to 1: 1 were randomly divided into
two groups, respectively take Erzhi Tiangui granule and placebo in a menstrual cycle, i.e.,
traditional Chinese medicine Erzhi Tiangui granule group 33 patients ( treatment group ),
placebo group with 33 patients (control group ). In two groups were observed before and
after treatment in patients with symptoms and signs to improve the situation,
administration time and number of FSH, before and after treatment of endometrial RI, PI.
After treatment take the endometriem in luteal phase, test the imprinted gene H19 using
PCR, RT-PCR combined with RFLP technique.The second cycle use the standard long
programme of IVF-ET ,statistics for each group of patients the implantation rate.
Redults: Treatment of a cycle, two to Tiangui granule group patients down -
regulated back, fatigue and other traditional Chinese medicine kidney yin deficiency
syndrome has been effectively improved, Gn less medication, medication days short,
endometrial typing and blood flow was significantly improved, and the implantation rate
was significantly higher than that of control group,
Conclusion: Medicine Erzhi Tiangui granule is the treatment of kidney-
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