嗅觉受体基因的研究进展.pdfVIP

HEREDITAS (Beijing) 2010 1 , 32(1): 17―24 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2010.00017 嗅觉受体基因的研究进展 1, 2 1 1 1 1 2 高一龙 , 缪勤 , 张汇东, 温海 , 秦海斌 , 谢庄 1. , 210012; 2. , 210095 嗅觉在动物的生命活动中起着重要的作用, 与嗅觉相关的基因主要是嗅觉受体(Olfactory receptor, OR) 基因。文章介绍了嗅觉受体基因的结构、表达调控、分布、分子进化及其多态性研究进展, 并讨论了该基因与 嗅觉功能和嗅觉障碍的关系。 嗅觉受体基因; 多态性; 嗅觉功能; 嗅觉障碍 Advances on olfactory receptor gene 1, 2 1 1 1 1 GAO Yi-Long , MIU Qin , ZHANG Hui-Dong , WEN Hai , QIN Hai-Bin , XIE Zhuang2 1. Nanjing Policedog Institute of the Ministry of Public Security, Nanjing 210012, China; 2. College of Animal Science and Technology, Nanjing Agriculture University, Nanjing 210095, China Abstract: The olfactory sense plays a key role in animals’life time. The main gene related with olfaction was olfactory receptor (OR) gene. This review introduced the structure, expression regulation, distribution, molecular evolution and polymorphism of OR gene. The relationship between OR gene and olfactory function and olfactory deficits was also dis- cussed Keywords: olfactory receptor gene; polymorphism; olfactory function; olfactory deficits , 2004 OR , , OR, OR , , [1, 2] 1 OR 1991 , LindaRichard[3] 1.1 OR (Olfactory receptor, OR), OR, , , ORG 收稿日期: 2009−05−06; 修回日期: 2009−07−29 作者简介: (