基于SPM动态因果模型操作练习.pptVIP

Dynamic Causal Modeling (DCM) A Practical Perspective Ollie Hulme Barrie Roulston Zeki lab Structure 1. Quick recap on what DCM can do for you. 2. What to think about when designing a DCM experiment 3. How to do DCM. What buttons to press etc. * Disclaimer The following speakers have never used DCM. Any impression of expertise or experience is entirely accidental. A Re-cap for Dummies You can ask different types of questions about brain processing. Questions of Where Questions of How Functional Specialization is a question of Where? Where in the brain is a certain cognitive/perceptual attribute processed? What are the Regionally specific effects ?your normal SPM analysis (GLM) Functional Integration is a question of HOW Experimentally designed input How does the system work?  What are the inter-regional effects? How do the components of the system interact with each other? MODEL-FREE MODEL-DEPENDENT Hypothesis driven DCM! Functional connectivity = the temporal correlation between spatially remote areas Effective connectivity = the influence one area exerts over another 2 Categories of Functional integration analysis PPI DCM overview DCM allows you model brain activity at the neuronal level (which is not directly accessible in fMRI) taking into account the anatomical architecture of the system and the interactions within that architecture under different conditions of stimulus input and context. The modelled neuronal dynamics (z) are transformed into area-specific BOLD signals (y) by a hemodynamic forward model (λ). The aim of DCM is to estimate parameters at the neuronal level so that the modelled BOLD signals are most similar to the experimentally measured BOLD signals. Planning a DCM-compatible study Experimental design: preferably multi-factorial (e.g. at least 2 x 2) Static Moving No attent Attent. 1.Sensory input factor At least one factor that varies the sensory input… changing the stimulus… a perturbation to the system 2. Cont