肿瘤学细胞周期精要.pptVIP

2001 Nobel Prize Interphase: – G1: gap – (G0: quiescent state during which cell cycle does not proceed) – S: replication of DNA and assembly of chromosomal proteins on daughter DNA molecules – G2: gap M phase: mitosis (nuclear division) cytokinesis (cytoplasmic division) 细胞增殖是生命的基本特征 初生婴儿1012个细胞，成人1014个，约200种类型。 成人体内每秒钟有数百万新细胞产生，以补偿衰老和死亡的细胞。 一个大肠杆菌若按20分钟分裂一次，并保持这一速度，则两天即可超过地球的重量。 Mechanisms involved in cell cycle control: Checkpoint regulation Differential cyclin gene expression Protein degradation (ubiquitin pathway) CDK activities regulated by – phosphorylation – binding of cyclins