西弗碱配合物的合成及表征.docVIP

L-谷氨酰胺席夫碱配合物的合成及其结构解析 摘要 席夫碱亦被称作西佛碱（Schiff base），其特有的官能团为亚胺或甲亚胺基（—RC=N—）。席夫碱是活性羰基和氨基通过化学反应缩合而成的产物，可作为有机试剂、液晶材料、磁学材料等在医药抗肿瘤、抗病毒、抑菌、荧光、色谱分析等领域均得到了广泛的应用并取得了巨大的进展[1]。而L-谷氨酸是生命体重要的氨基酸，其在自然界中有着广泛的存在。L-谷氨酰胺的锂盐与草酸二乙酯以及大茴香醛所形成的配位化合物亦具有席夫碱在药理学和生理活性上良好的表现。 在本文中主要介绍L-谷氨酰胺的钾盐、锂盐与草酸二乙酯、大茴香醛所形成的配体其与多种金属盐特别是铜盐所形成的配合物的结构及药理特性。通过借助化学软件ChemcalDraw，oringe等对其进行结构分析和红外谱图的分析，对其结构特性进行表征[2]。以下为实验工作过程： （1）L-谷氨酰胺为主的配体与多种金属盐离子形成多样的金属配合物.通过查阅资料和借助化学仪器得知L-谷氨酰胺所形成的配体在不同的反应条件下所形成的配合物亦不相同，而本文主要介绍其配体与金属盐离子按照1:1的比例进行反应，羰基失质子与铜、镍、锌等金属离子结合，α-氨基与金属盐离子以共价键的形式结合所形成的配合物。 （2）L-谷氨酰胺与氢氧化锂或氢氧化锂反应所形成的盐与以草酸二乙酯和大茴香醛等有机物反应形成配体，在通过探索配体与铜、镍、锌、镁等金属盐在一定条件下形成金属配合物。 通过红外光谱分析、元素分析和借助抗菌试验等对合成的配合物进行表征和分析。 关键词：L-谷氨酰胺 草酸二乙酯 大茴香醛 配体 Schiff base配合物 铜、锌、镁金属盐 Abstract L-glutamine Schiff base complexes Synthesis and structural analysis thereof Schiff bases are also known as Schiff base (Schiff base), its unique functional groups imine or azomethine (-RC = N-). Schiff base is a product of reactive carbonyl groups and amino condensation formed by a chemical reaction can be used as organic reagents, liquid crystal materials, magnetic materials, etc. in the pharmaceutical anti-tumor, anti-viral, antibacterial field, fluorescence, chromatography, etc. have been widely application and has made tremendous progress. And L-glutamic acid is an important amino acid beings, which has been widely exist in nature. L-glutamine coordination compounds with lithium diethyl oxalate salt and anise aldehyde formed Schiff base also has the pharmacological and physiological activity of a good performance. In this article describes the structure and the pharmacological properties of the ligand L-glutamine potassium, lithium diethyl oxalate, anisic aldehyde formed with various copper salts, especially the formed complexes . By means of chemical software ChemcalDraw, oringe be analyzed, such as structural analysis and infrared spectra, and its structural properties were characterized. The following is an experimental