口腔精准医学：现状和挑战.pdfVIP

33 3 2015  6 华西口腔医学杂志 第 卷 第 期 年 月   West China Journal of Stomatology Vol.33 No.3 Jun. 2015 •315 • [文章编号] 1000-1182(2015)03-0315-07 ·综述· 口腔精准医学：现状与挑战 徐欣 郑欣 郑黎薇 程磊 周学东 口腔疾病研究国家重点实验室 华西口腔医院（四川大学），成都 610041 [摘要] 精准医学是人类基因组计划的延续，是医学发展的必然产物，是一种考虑人群基因、环境及生活方式个体 差异的促进健康和治疗疾病的新兴医学模式。本文首次提出口腔精准医学的概念，以口腔典型疾病为例，结合近期 的研究成果与学者观点，阐述口腔精准医学对口腔学科发展的指导意义及实现口腔精准医学将面对的机遇与挑战。 [关键词] 精准医学； 口腔精准医学； 个体化医疗； 生物样本库 [中图分类号] R 78 [文献标志码] A [doi] 10.7518/hxkq.2015.03.021 Precision stomatology: current status and challenges Xu Xin, Zheng Xin, Zheng Liwei, Cheng Lei, Zhou Xuedong. (State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) [Abstract] The completion of human genome project and the progress in medical practice have inevitably lead to the deve- lopment of precision medicine, which is a medical model that proposes the customization of medical care including medical decisions, practices, and/or medical products with patient’s genetic background, environmental factors and life behavior being taken into account. The current work proposed precision stomatology for the first time, and by integrating data reported in recent literature, we described the current practice of precision stomatology in multiple disciplines in modern dentistry. The clinical significance of precision stomatology and its future challenges have also been discussed. [Key words] precision medicine; precision stomatology; personalized medicine; biobank 2011年美国科学院、美国工程院、美国国立卫 诊治与预防效益。 生研究院及美国