trek1钾通道及抑郁症.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 12, 47 ( 11): 1403 1408 ·1403 · ·综述· TREK1 钾通道与抑郁症 1, 2 1* 2* 叶冬青 , 张志珺 , 李 扬 ( 1. 东南大学神经精神医学研究所, 江苏 南京 2 10009; 2. 中国科学院上海 物研究所, 上海 20 1203) 摘要: 抑郁症日益成为全球性社会问题, 但是其致病机制目前尚不明确。最近研究表明, 双孔钾通道TREK1 可能是新的抗抑郁 物的作用靶点。本文综述了双孔钾通道的结构与功能研究进展以及该通道与抑郁症的关系, 着重阐述了 TREK1 钾通道在抗抑郁、神经保护和神经重塑等过程中的重要作用, 并说明了TREK1 钾通道与单 胺类递质及其受体的相互作用的分子机制。本文还讨论了今后与抑郁症相关的重要的研究方向。 关键词: 双孔钾通道; TREK 1; 抑郁症; 神经保护; 神经重塑 中图分类号: R963 文献标识码: A 文章编号: 05 13-4870 (20 12) 11-1403-06 TREK1 potassium channels and depression YE Dong-qing1, 2, ZHANG Zhi-j un1*, LI Yang2* (1. Institute of Neurology and Psyc hiatry, Southeast University, Nanj ing 210009, China; 2. Shanghai Institute of Materia Medica, Chinese A cademy of Sciences, Shanghai 201203, China) Abstract: Maj or depression disorder is an increasing heavy burden in modern society, but its pathological mechanism is still vague. Recent evidence indicated that two pore potassium channel, TREK 1, is one of the important drug targets of antidepressants. The structural and functional research progress of TREK 1 potassium channel were reviewed with an emphasis on its roles in anti-depression, neuronal protection, and neuronal plasticity. The complicated interactions between TREK 1 potassium channel and monoamine transmitters- receptors were also reviewed and future directions to explore the underline mechanism were also discussed. Key words: two pore potassium channel; TREK 1; depression; neural protection; plasticity 随着经济的高速发展和社会竞争日趋激烈, 抑 的重要成员。