甲地孕酮联合羟考酮缓释片和放疗治疗前列腺癌骨转移疼痛的临床观察.docVIP

甲地孕酮联合羟考酮缓释片和放疗治疗前列腺癌骨转移疼痛的临床观察 　　【摘要】 目的：探讨醋酸甲地孕酮分散片联合盐酸羟考酮缓释片和放疗治疗前列腺癌骨转移的安全性和有效性的临床观察。方法：将前列腺癌骨转移患者随机分为两组，试验组34例，给予盐酸羟考酮缓释片常规镇痛治疗联合醋酸甲地孕酮，待疼痛控制稳定后给予前列腺+骨转移放疗；对照组35例，给予盐酸羟考酮缓释片常规镇痛治疗，待疼痛控制稳定后给予前列腺+骨转移放疗。观察两组盐酸羟考酮缓释片药物用药剂量大小、维持治疗时间、毒副反应情况及疼痛控制情况的变化。结果：试验组盐酸羟考酮缓释片药物维持剂量较小、维持治疗时间短、毒副反应轻（恶心呕吐和便秘），且疼痛控制情况好，与对照组比较差异均有统计学意义（P中国论文网 /6/view-7251438.htm 　　【关键词】 甲地孕酮； 盐酸羟考酮缓释片； 放疗； 前列腺癌 　　Clinical Observation of Megestrol Acctate Combined with Oxycodone Hydrochloride Sustained-release Tablets and Radiotherapy for the Pain of Bone Metastasis of Prostate Cancer/ZHANG Han-qun，NI Ting-ting， LI Hang，et al.//Medical Innovation of China，2016，13（06）：011-014 　　【Abstract】 Objective： To investigate the Megestrol Acetate Dispersible Tablets combined with Oxycodone Hydrochloride Sustained-release Tablets and radiotherapy for bone metastasis of prostate cancer on the safety and efficacy of clinical observation.Method： The prostate cancer patients with bone metastasis were randomly divided into two groups， the experimental group had 34 cases， they were treated with conventional analgesic Oxycodone Hydrochloride Sustained release Tablets combined with Megestrol Acetate， for pain control stability after radiotherapy of prostate and bone metastasis. 35 cases in the control group， they were treated with conventional analgesic therapy of sustained release tablets of Oxycodone Hydrochloride for pain control， stable after radiotherapy for prostate and bone metastasis. The sustained release tablets of Oxycodone Hydrochloride drug dosage size， maintenance treatment time， drug toxicity， change the control of pain between the two groups were observed. Result：The experimental group of sustained release tablets of Oxycodone Hydrochloride drug maintenance dosage was small， maintain the treatment time was short， mild side effects （nausea and vomiting and constipation） were light， pain control was good， there were statistically significant differences compared with the control group （P 　　First-authors