脂肪干细胞促进周围神经损伤后再生.docVIP

脂肪干细胞促进周围神经损伤后再生 周围神经损伤后的自身功能恢复往往有限，因此，生物工程神经移植物复合细胞外基质分子，生长因子,药物学辅助，及细胞移植修复周围神经损伤等都成为研究热点。脂肪干细胞已被证实具有成脂肪，成骨，成软骨 多种分化潜能，因其材料来源广泛，取材容易，分化为神经元能力强，伦理学争议少等优点，使其成为神经导管上覆盖的优秀种子细胞。英国曼彻斯特大学炎症与修复研究所Blond McIndoe 实验室主要研究GABA及其他神经递质周围神经系统及成体干细胞中的作用，他们发现，特异性抑制P2X7受体能够拯救ATP诱发细胞死亡，这可能解决神经损伤处干细胞移植成活率低的问题。作者的研究可能为神经修复结合细胞疗法和药物干预的发展指出新的方向。相关研究观点发表在《中国神经再生研究（英文版）》杂志2014年7月第14 期杂志上。 Article: “Adipose derived stem cells and peripheral nerve regeneration” by Alessandro Faroni, Richard JP Smith, Adam J Reid (1 Blond McIndoe Laboratories, Institute of Inflammation and Repair, University of Manchester, Manchester, UK; 2 Department of Plastic Surgery Burns, University Hospital of South Manchester, Manchester, UK) Faroni A, Smith RJP, Reid AJ. Adipose derived stem cells and peripheral nerve regeneration. Neural Regen Res. 2014;9(14):1341-1346. 欲获更多资讯： Neural Regen Res Adipose Derived Stem Cells and Nerve Regeneration SUMMARY Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. This prospect examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts. NEWS RELEASE Stem cell researchers at the Blond McIndoe Laboratory, University of Manchester, UK, led by Dr Adam Reid, present a review of the current literature on the suitability of adipose-derived stem cells in peripheral nerve repair. Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment relies on sacrificing a nerve from elsewhere in the body to provide a nerve graft at the injury site, but much work has been done to develop a bioengineered nerve graft that would not require this sacrifice. Stem cells are prime candidates as accelerators of