严重多发伤患者外周血中性粒细胞中核因子κB与炎症介质的变化.docVIP

严重多发伤患者外周血中性粒细胞中核因子κB与炎症介质的变化 　　[摘要] 目的 探讨及观察严重多发伤患者外周血中性粒细胞中核因子κB与炎症介质的变化。 方法 选择2013年3月～2015年4月于四川省人民医院进行治疗的65例严重多发伤患者为观察组，选取同期进行体检健康者65名为对照组，然后将观察组伤后24、48 h及72 h时的外周血中性粒细胞中核因子κB与抗炎介质、促炎介质水平与对照组分别进行比较，并将观察组中非多器官功能障碍综合征（MODS）与MODS者、存活与死亡者的上述检测指标水平分别进行比较。 结果 观察组伤后24、48 h及72 h时的外周血中性粒细胞中核因子κB与抗炎介质、促炎介质水平均明显高于对照组，且伤后48、72 h的外周血中性粒细胞中核因子κB高于伤后24 h，伤后72 h的抗炎介质、促炎介质水平高于伤后24 h，且观察组中MODS及死亡者的检测水平均高于非MODS及存活者，差异均有统计学意义（均P 中国论文网 /6/view-7218235.htm 　　[关键词] 外周血中性粒细胞；核因子κB；炎症介质；严重多发伤 　　[中图分类号] R651.15 [文献标识码] A [文章编号] 1673-7210（2016）01（a）-0062-05 　　Change of peripheral blood neutrophil nuclear factor κB and inflammation mediators of patients with severe multiple injuries 　　LI Wei ZENG Jie 　　Department of Emergency Surgery， Sichuan Provincial People’s Hospital， Sichuan Province， Chendu 610072， China 　　[Abstract] Objective To investigate and observe the change of peripheral blood neutrophil nuclear factor κB and inflammation mediators of patients with severe multiple injuries. Methods 65 patients with severe multiple injuries from March 2013 to April 2015 in Sichuan Provincial People’s Hospital were selected as observation group， 65 healthy persons with health examination at the same time were selected as control group， then the peripheral blood neutrophil nuclear factor κB， anti-inflammatory mediators and pro-inflammatory mediators of observation group at 24， 48 h and 72 h after injury and control group were respectively compared， and those detection indexes of observation group with non-MODS and MODS， survival and death were respectively compared too. Results The peripheral blood neutrophil nuclear factor κB， anti-inflammatory mediators and pro-inflammatory mediators of observation group at 24， 48 h and 72 h after injury were all obviously higher than those of control group，and the peripheral blood neutrophil nuclear factor κB of the observation group at 48 h and 72 h after injury were higher than 24 h after injury， and the anti-inflammatory mediators and pro-inflammatory