淋巴细胞概述.ppt

  1. 1、本文档共33页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
* CD5 B Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y Y IgM B-1细胞的主要生物学功能 -主要识别TI-2抗原的多糖类物质,如荚膜多糖,聚合鞭毛素等; - 参与对多种细菌(尤其体腔中)的抗感染免疫; - 产生低亲和力IgM类的生理性自身抗体,参与对衰老、蜕变自身细胞的清除; - 通过产生IgM类自身抗体参与某些自身免疫病的发生 * B Mature B-2 B cell CD5- B-2 细胞的主要生物学功能 - 参与体液免疫应答: BC+Ag?在Th辅助下? 活化增殖 ?分化浆细胞? 产生高亲和力抗体 - 抗原提呈: BC用BCR摄取Ag ? 处理肽+MHCII ? 提呈抗原给CD4T细胞,提供协同信号 - 免疫调节: 活化BC产生多种细胞因子,参与免疫调节 Y Y Y Y Y Y IgG * B细胞亚群及功能 * 小 结 掌握B细胞的表面标志及其功能。 熟悉B细胞的亚类及功能。 * * * foetal * In the process of B cell development there are three important events: The first is generation of functional BCR by rearrangenment of BCR gene segments to generate BCR diversity. The second is negative selection by which the self reactive B cell clones are eliminated. In this way self tolerance is established.. The third one is positive selection which occurs not in bone marrow but in geminal centers of peripheral lymphoid organs after maturation of B cells. This is very different from development of T cells. Because the mature T cell does not undergo any selections in the periphery. The mature B cells in germinal centers undergo somatic mutation. This is followed by positive selection. Only those B cells with high affinity are positively selected to survive. This process is the basis of affinity maturation of BCRand antibodies. * In the process of B cell development there are three important events: The first is generation of functional BCR by rearrangenment of BCR gene segments to generate BCR diversity. The second is negative selection by which the self reactive B cell clones are eliminated. In this way self tolerance is established.. The third one is positive selection which occurs not in bone marrow but in geminal centers of peripheral lymphoid organs after maturation of B cells. This is very different from development of T cells. Because the mature T cell does not undergo any selections in the periphery. The mature B cells in germinal centers undergo somatic mutation. This is followed by positive selection. O

文档评论(0)

boss + 关注
实名认证
内容提供者

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档