T淋巴细胞及T细胞免疫应答材料.ppt

Th细胞 根据所分泌的细胞因子不同，将其分为Th0、Th1和Th2亚型。 Tc细胞 杀伤、分泌IFNγ、IL-4、IL-5和IL-10 Ts细胞 TDTH 主要为CD4 + Th1 4）初始T细胞和记忆性T细胞 记忆性T细胞表达CD45RO，而初始T细胞表达CD45RA 5）NK1.1 T细胞 其TCR识别的抗原是由CD1分子提呈的脂类和糖脂类抗原 一、T细胞对抗原的识别 四、转录因子活化及基因表达 T细胞介导免疫应答及其免疫学效应 三、T淋巴细胞活化信号的转导过程 抗原作用下跨膜分子及信号转导成分的多聚化 多聚作用（multimerization）: TCR/CD3、辅助受体CD4或CD8、CD45等相互靠拢成簇（clustering） 免疫受体酪氨酸激活基序 （immunoreceptor tyrosine-based activation motif, ITAM） ……D/Exx YxxL/V x(7~11) YxxL/V …… Y：酪氨酸 L：亮氨酸 V：缬氨酸 D：天冬氨酸 E：谷氨酸 T细胞活化的信号传导 （一）转录因子活化 AP-1 (Fos、Jun) NF-?B Oct-1 NFAT (nuclear factor of activated T cell ) Treg-based immune intervention strategies. Selective manipulation of Treg function is an emerging target for immune intervention strategies to either boost responses in cancer and microbial diseases or suppress those unwanted in autoimmunity, allergy, transplantation and pregnancy disorders. The transient depletion of Tregs as well as their modulation by microbial agents may allow a transient reduction of Treg activity and enforce anti-tumor responses and immunity against viral infections. On the other hand their selective activation could diminish chronic pathological immune responses Generation and conversion of Treg cells in the tumor microenvironment Tumor cells not only provide antigenic stimulation for T cell activation but also interact with tumor-infiltrating innate immune cells to secrete crucial cytokines for T-cell differentiation. Na?¨ve CD4+ T cells can be differentiated into different subsets of CD4+ T cells, including Th1, Th2, Treg and IL-17-producing T cells (Th17), depending upon the strength of antigen stimulation and cytokine milieu. It is known that combination of suboptimal antigen stimulation with TGF-b favors the conversion of naive T cells into Treg cells but blocks the generation of Th1 or Th2 cells. However, TGF-b plus IL-6 facilitate the conversion of naive T cells into Th17 cells. Alternatively, naturally occurring CD4+CD25+ Treg cells directly derived from the thymus can cross-react with