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ABSTRACT
anew isolated
immunosuppressant,was
C(K-C),as
Kanglemycin
vat 1747—64.
mediterranei
filtrateofNocardia
t}omtheculture kanglensis
that
studiesindicated
Ithasflew asshownin 1.Previous
a structure Figure
the
sensitivetooxidationin
is
bond inthisstructure process
singleC12a—C6a
ofisolationand
purification.
the of
In valuesand to
this stability
ofpH temperatures
study,effects
at
the ofK—Cdeclines
resultsshowed
K-Cwereexamined.The stability
also atcertain
valvesastemperaturegoesupand lowers
givenpH
be
as value the will
temperaturespH rises,andcompoundcompletely
at withinhours.The of
oxidized 24
8,37。C relationshiptemperature,
pH
valuesand ofK-C theisolationand ofK—
pH stabilitysuggests purification
C be low and
should at temperat
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