新活素科会终结版0118-2.pptVIP

这是给药期间24小时心动监测的结果，多巴酚丁胺室性心律不齐发生率明显高于脑利钠肽组。 该试验有力地证明了脑利钠肽与多巴酚丁胺比较，无致室性心律失常作用，那末对于患者再住院率和远期死亡率作用又如何呢？ (注释：该文献为脑钠肽与多巴酚丁胺比较，室性心律失常发生率的比较性研究) Reference: Burger AJ, Elkayam U, Neibaur MT, et al. Comparison of the occurrence of ventricular arrhythmias in patients with acutely decompensated congestive heart failure receiving dobutamine versus nesiritide therapy. Am J Cardiol. 2001;88:35–39. In a multicenter, open-label study, patients were randomized to receive standard care; nesiritide, 0.015 μg/kg/min infusion, preceded by a 0.3 μg/kg bolus; or nesiritide, 0.030 μg/kg/min, preceded by a 0.6 μg/kg b