杰诺维DPP__4抑制剂的同和异.pptVIP

宝山壁画 宝山壁画是引人注目的昂贵文物。此壁画发现于阿鲁科尔沁旗东沙布乡境内。1994年列为“全国十大考古新发现”之一。宝山壁画中最引人注目的是《杨贵妃教鹦鹉图》。该画高0.7米、宽2.3米，用于笔重彩绘制，最突出的表现了 晚唐风格。唐代擅长绘贵妇仕女的大师周昉绘制了《杨贵妃教鹦鹉图》，不仅享誉中原，而且还影响全国各地。发现于阿旗宝山古墓里的这幅画，就是契丹人聘请中原画家按照周氏风格绘制的， 技法深得周氏画风的真传。在唐人真迹稀如星风的今天，能够从中完整了解唐代人物画的杰出成就，堪称美术史研究的辛事。这幅壁画现今保存在阿鲁科尔沁旗博物馆，历经千年，恍如新绘，是该馆的镇馆之宝。 欢迎大家观看！ 1.All the China registration studies were conducted in China or in Asian countries (China was included). 2.About the combination therapy: 1) Patients with A1C 7.5-11.0% who were on metformin 1000mg/d or 1700mg/d were randomized to receive additional sitagliptin 100 mg qd. 2) Patients with A1C 7.0-10% who were on metformin therapy with a stable dose ≥1500mg /d were randomized to receive additional vildagliptin 50mg qd or 50 mg bid (n=146) in the vildgliptin registration study. Vildagliptin monotherapy clinical trial was not conducted in China. 3) Patients on stable metformin ≥1500mg /d (the maximal dose was 2500mg/d in Chinese patients) were eligible to add saxagliptin 5 mg qd if they were with A1c 7-10%. * we selected 90 type 2 diabetic patients (43 men and 47 women) without adequate glycemic control (HbA1c.7.5%) on metformin treatment at maximal dose (2,000 mg/day) for at least 8 weeks before enrollment. A prospective, randomized, open-label PROBE design (parallel group with a blinded end point) study was performed. The study assigned 45 patients to receive sitagliptin (100 mg once daily; sitagliptin group) and 45 patients to receive vildagliptin(50 mg twice daily; vildagliptin group) for 12 weeks.HbA1c baseline 8.5% * * 糖尿病患者的肝肾功能是治疗中经常被考虑的问题，捷诺维在肾功能不全的患者进行剂量调整，就可以安全使用。在轻、中度肝功能不全的患者，也可以使用。 沙格列汀不推荐在中、重度肾功能、重度肝功能不全患者的使用，在中度肝功能不全患者中，无需调整剂量但需谨慎使用。 维沙格列汀不被推荐在中、重度肾功能，轻、中、重度肝功能不全患者中处方。 We included studies in this meta-analysis if (1) they were RCTs comparing DPP4 inhibitor monotherapy in 1 arm to other oral antitype 2 DM agents (other than DPP4 inhibitors) in the comparator arm, (2) duration of treatment was 24 weeks, and (3) reported data on adverse CV side eff