116例中枢神经系统特发性炎性脱髓鞘病中痛性强直痉挛患病率调查研究.pdf

异。(2)本组资料表明，痛性强直痉挛对于中枢神经系统特发性炎性脱髓鞘病的诊断 虽然灵敏度不高，但是特异度均很高，可以认为，一旦发生痛性强直痉挛，对中枢神 经系统特发性炎性脱髓鞘病的诊断具有较大的参考价值。(3)本组资料表明，痛性强 直痉挛累及的肢体以双下肢及四肢较常见，其发病与中枢神经系统的病灶有关，病变 部位可以位于脊髓，亦可以位于脊髓外的中枢神经系统，而颈髓及胸髓是其好发的病 变部位。 关键词 中枢神经系统特发性炎性脱髓鞘病；痛性强直痉挛；患病率；调查 Prevalence Survey of Painful Tonic Spasms in 1 16 Patiens with Idiopathic Inflammatory Demyelinating Diseases of the Central Nervous System Abstract Objective To investigate the prevalence rate of painful tonic spasms in patiens with Idiopathic Inflammatory Demyelinating Diseases of the Central Nervous System and to analyse its clinical worth by a retrospectiVe review． Methods According to the paper“consensus of experts about the diagnosis and the treatment of Multiple SclerosiS and related central nervous system demyelinating diseases in Chinaby the Chinese Medical Association of neuropathy in 2006 and“the cl inical progress of Idiopathic Inflammatory Demyel inating Diseases by QI Xiaokun in 2008，a retrospective survey was performed at department of neurology in our hospital from March 2008 to December 2009．The prevalence of painful tonic spasms rate was analysed in statistiCS and the results were contrasted between di fferent classification whether there was any statistical difference．Furthermore，the sensitivity， specificity and predictive value for the diagnosis of each subgroup disease were calculated，and the limbs and pathogenic lesions suffered from painful tonic spasms regularly were calculated to observe its cl inical worth． Results(1)In this study，1 16 patients with IIDDs were included．Among them， patients with painful tonic spasms were 13 cases．And the prevalence rate of painful tonic spasms was 1 1．2％in IIDDs．The prevalence rate of painful tonic spasms in the subgroup of 31 patients with MS was 12．9％．The prevalence rate of painful tonic spasms in 16 patients with NMO was 18．8％．And the other prevalence rate was 0％and 9．5％individually in 6 patients with ADEM and 63 patients with CIS．There was no staristical difference about the pr